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Comprehensive Pet Therapy, Sandy Springs, GA, USA DOI Published 2014-09-30 Accepted 2014-09-04 Received 2014-07-03 Academic Editor Subject Areas,, Keywords fMRI, Canine cognition, Animal temperament, Caudate, Neuroimaging, Comparative neuroscience, Reward systems Copyright © 2014 Cook et al. Licence This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. Cite this article Cook PF, Spivak M, Berns GS. One pair of hands is not like another: caudate BOLD response in dogs depends on signal source and canine temperament.

PeerJ 2: e596. Having previously used functional MRI to map the response to a reward signal in the ventral caudate in awake unrestrained dogs, here we examined the importance of signal source to canine caudate activation. Hand signals representing either incipient reward or no reward were presented by a familiar human (each dog’s respective handler), an unfamiliar human, and via illustrated images of hands on a computer screen to 13 dogs undergoing voluntary fMRI. All dogs had received extensive training with the reward and no-reward signals from their handlers and with the computer images and had minimal exposure to the signals from strangers.

All dogs showed differentially higher BOLD response in the ventral caudate to the reward versus no reward signals, and there was a robust effect at the group level. Further, differential response to the signal source had a highly significant interaction with a dog’s general aggressivity as measured by the C-BARQ canine personality assessment. Dogs with greater aggressivity showed a higher differential response to the reward signal versus no-reward signal presented by the unfamiliar human and computer, while dogs with lower aggressivity showed a higher differential response to the reward signal versus no-reward signal from their handler.